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. 2022 Aug 17;2022:6422202. doi: 10.1155/2022/6422202

Figure 6.

Figure 6

Macrophage depletion reduces angiogenesis after delayed recanalization. (a) Representative images of macrophages via F4/80 immunohistochemical staining in the spleen. (b) Quantification of macrophage in each group. (c) Western blotting analysis of macrophage marker F4/80 expression. (d) Quantification of macrophage marker F4/80 expression in spleen. (e) Western blotting analyses of macrophage, neuroinflammation, and angiogenesis markers. (f–h) Quantification of related proteins in each group. (l) Representative images of microvessel density in the peri-infarction area visualized by immunohistochemical staining with lectin. Error bars represent the mean ± SD. ∗P < 0.05 and ∗∗P < 0.01 vs. sham group; #P < 0.05 and ##P < 0.01 vs. rMCAO group; &P < 0.05 and &&P < 0.01 vs. rMCAO+PBS (n = 5).