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. 2022 Aug 10;608(7924):724–732. doi: 10.1038/s41586-022-05072-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (A) Estimates of the mutation rate across non-Ig chromosomes and Ig regions for memory (left) and naive B (right) cells. Rates for the Ig regions are calculated separately for the productive (triangles) and non-recombined alleles (circles) and exons (green) versus introns (orange). (B) Estimated mutation rates across different variable segments of the Ig genes for exons (green) versus introns (orange). (C) Number of productive V(D)J rearrangements affecting each variable segment in the dataset. (D) Proportion of mutations across chromosomes 2, 14 and 22 in each 1Mb window attributed to signatures SBS9, SBSblood and the canonical somatic hypermutation (SHM) signature (rows). Windows spanning the relevant immunoglobulin regions are coloured according to the key.