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. 2022 Aug 10;608(7924):724–732. doi: 10.1038/s41586-022-05072-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (A) Indel mutation burden per genome for the four main lymphocyte subsets (pink points), compared with HSPCs (green points). Each panel has all genomes plotted underneath in white with grey outline. The lines show the fit by linear mixed effects models for the respective populations. (B) Plots of the estimated dN/dS ratio for mutations genome-wide (excluding immunoglobulin genes) for all lymphocytes, and for the various individual lymphocyte populations. The second row shows the estimated dN/dS ratio for known cancer genes in all lymphocytes. The diamond shows the point estimates, and the lines the 95% confidence intervals. The point estimates / number of variants included in each analysis are as follows: lymphocytes, genome-wide = 1.12 / 7555; lymphocytes, cancer genes = 1.21 / 352; naive B = 1.25 / 671; memory B = 1.10 / 1132; naive T = 1.16 / 4162; memory T = 0.99 / 1414.