Table 1.

Global consumption of antifungal agents from 2008 to 2018 in 65 countries

Drug name	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	CAGRa 2008–2018 (%)
Echinocandins
Anidulafungin	0.000189	0.000227	0.000228	0.000233	0.000249	0.000311	0.000378	0.000468	0.000548	0.000595	0.000612	12.45
Caspofungin	0.000957	0.000912	0.000896	0.000874	0.000908	0.000945	0.000981	0.000991	0.001014	0.001033	0.001230	2.54
Micafungin	0.000936	0.001167	0.001364	0.001520	0.001614	0.001620	0.001636	0.001677	0.001743	0.001741	0.001718	6.26
Imidazoles
Ketoconazole	0.061129	0.060694	0.062981	0.061724	0.063225	0.060383	0.047105	0.044064	0.040954	0.039156	0.036422	− 5.04
Miconazole	0.000078	0.000065	0.0000595	0.000053	0.000051	0.000043	0.000040	0.0000373	0.000028	0.000030	0.000029	− 9.34
Polyeneb
Amphotericin B	0.003285	0.003399	0.003613	0.003663	0.003741	0.003804	0.003696	0.003682	0.003659	0.003754	0.00394	1.82
Triazoles
Fluconazole	0.144044	0.170108	0.181778	0.197279	0.182574	0.186588	0.194213	0.203014	0.208883	0.220232	0.229617	4.77
Isavuconazole								0.000498	0.002039	0.003811	0.005622	124.27
Itraconazole	0.066135	0.065450	0.066679	0.070892	0.076629	0.077068	0.081803	0.096189	0.141494	0.237012	0.324027	17.22
Posaconazole	0.003072	0.003226	0.003449	0.004237	0.004768	0.004990	0.005433	0.004434	0.003986	0.004010	0.004503	3.90
Voriconazole	0.003507	0.003700	0.004022	0.004631	0.005160	0.005461	0.005522	0.005862	0.006260	0.006711	0.007383	7.73
Others
Terbinafine	0.217883	0.221046	0.226815	0.232156	0.233199	0.237763	0.254827	0.271679	0.289722	0.298927	0.302938	3.35
Flucytosine	0.000053	0.000082	0.000188	0.000208	0.000151	0.000130	0.000133	0.000132	0.000113	0.000110	0.000119	8.37

Consumption shown as defined daily dose per 1000 inhabitants per day

CAGR compound annual growth rate

^aData on isavuconazole was not available from 2008 to 2014 since it was approved later

^bAmphotericin B formulations include both conventional and lipophilic formulations of amphotericin B