Irritable bowel syndrome (IBS) is a commonly encountered disorder of gut–brain interactions characterized by recurrent abdominal pain and altered defecation

Symptoms of IBS with diarrhea (IBS-D) overlap with other conditions frequently encountered by primary care providers

Diagnosis of IBS-D relies primarily on symptom-based criteria, with the addition of minimal fecal and serologic testing to increase confidence in diagnosis

IBS-D management strategies involve nonpharmacologic and pharmacologic therapies