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. 2022 Aug 24;12:14428. doi: 10.1038/s41598-022-13272-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Diagnostic prediction (Receiver Operating Characteristics (ROC) curves and area under the curve (AUC) values) of the selected serum liquid biopsy biomarkers. AUC values were calculated by stepwise logistic regression algorithm, and then the graphs were drawn by R's own program. CO9, LBP, SVEP1 and VWF levels for diagnosing patients with chronic hepatitis B virus infection (CHB) (A), liver cirrhosis (LC) (B), and hepatocellular carcinoma (HCC) (C) compared with healthy controls (HCs). AUC values of VWF as a marker for diagnosing CHB compared with LC (D). AUC values of CO9 as a marker for diagnosing CHB compared with HCC (E). AUC values of KV311 as a marker for diagnosing LC compared with HCC (F).