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. 2022 Aug 24;12:14428. doi: 10.1038/s41598-022-13272-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of differentially expressed proteins identified in serum EVs (sEVs). The Bubble plots were drawn by the R program. And the R program was written after enrichment significance, which was calculated by Fisher’s exact test. Bubble plots showing enrichment for the GO biological process (A), cellular component (B), and molecular function (C). A bubble plot showing enrichment for KEGG pathways (D).