Table 3.
Classification of fusions detected in 61 glioblastoma samples: fusions not previously detected in healthy tissue or cancer but involving an oncogene or TSG (N = 21).
| Fusion | Detected in no. samples | Left gene | Right gene | Type of fusion | ||||
|---|---|---|---|---|---|---|---|---|
| Oncogene or TSG? | Previously described in cancer? | In fusions with other genes in glioma? | Oncogene or TSG? | Previously described in cancer? | In fusions with other genes in glioma? | |||
| RP11-384F7.2::LSAMP | 13 | No | No | No | Possible TSG | No | LG | Unknown |
| GNAQ::CEP78 | 1 | Oncogene | Yes | No | No | No | No | Frame-shifted |
| MALAT1::EGFR | 1 | Oncogene | Yes | No | Oncogene or TSG | Yes | HG & LG | Unknown |
| MITF::ST18 | 1 | Oncogene | Yes | No | No | No | No | Unknown |
| RERE::PSMD6 | 1 | Oncogene | Yes | LG | No | No | No | Frame-shifted |
| VPS53::VWDE | 1 | Possible TSG | No | LG | No | No | No | Frame-shifted |
| XRCC5::LINC01614 | 1 | Possible TSG | No | LG | No | No | No | Unknown |
| ABL1::SZRD1 | 1 | Oncogene or TSG | Yes | No | No | No | No | In-frame / Frame-shifted |
| AGAP2::KIF5A | 1 | Oncogene or TSG | Yes | GB | No | No | HG & LG | In-frame |
| CDK6::RP11-745C15.2 | 1 | Oncogene or TSG | Yes | No | No | No | No | Unknown |
| EGFR::R3HDM2 | 1 | Oncogene or TSG | Yes | HG & LG | No | No | GB | In-frame |
| EGFR::RP11-745C15.2 | 1 | Oncogene or TSG | Yes | HG & LG | No | No | No | Unknown |
| HMGA2::LLPH | 1 | Oncogene or TSG | Yes | GB | No | No | No | Frame-shifted |
| JAZF1::SEPT7P5 | 1 | Oncogene or TSG | Yes | HG & LG | No | No | No | Unknown |
| STAT3::CFAP61 | 1 | Oncogene or TSG | Yes | No | No | No | No | Unknown |
| USP22::TMC3 | 1 | Oncogene or TSG | No | No | No | No | LG | In-frame |
| BEST3::EGFR | 1 | No | No | No | Oncogene or TSG | Yes | GB | Unknown |
| C3orf62::PBRM1 | 1 | No | No | No | Oncogene | Yes | LG | Frame-shifted |
| CEP78::GNAQ | 1 | No | No | No | Oncogene | Yes | No | In-frame |
| CTDSP2::GLI1 | 1 | No | No | GB & LG | Oncogene or TSG | Yes | HG & LG | In-frame |
| SLC35E3::EGFR | 1 | No | No | GB | Oncogene or TSG | Yes | HG & LG | Frame-shifted |
TSG tumor suppressor gene, LG low-grade glioma, HG high-grade glioma, GB glioblastoma.