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. 2021 Oct 4;75(1):107–117. doi: 10.1093/cid/ciab864

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© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Cumulative incidence of (A) virologically confirmed dengue (VCD) cases and (B) hospitalized VCD cases, from the first dose to 3 years after the second dose (approximately month 39 after first dose; safety set data). Number of cases prevented per 100000 participants vaccinated is calculated as 100000/number needed to treat (NNT). NNT is calculated as the reciprocal of risk difference. Risk difference is calculated as the number of events divided by the number of participants evaluated in the placebo group, subtracted by the number of events divided by the number of participants evaluated in the TAK-003 group.