TABLE 1.
Baseline characteristics of cognitively normal participants
| All (N = 8168) | nHW (n = 6313) | AA (n = 1250) | Hispanic (n = 390) | Asian (n = 186) | AIAN (n = 29) | P | |
|---|---|---|---|---|---|---|---|
| Age (y) (n = 8168) | 74.9 ± 7.0 | 75.34 ± 7.19 | 73.54 ± 6.22 a | 72.86 ± 6.06 a | 73.61 ± 5.71 a | 72.28 ± 6.82 | <.001 |
| Age range | (65‐102) | (65‐102) | (65‐101) | (65‐90) | (65‐91) | (65‐94) | |
| Sex (n = 8168) | <.001 | ||||||
| Female | 5398 (66.09%) | 3972 (62.92%) a | 1006 (80.48%) a | 277 (71.03%) | 119 (63.98%) | 24 (82.76%) | |
| Male | 2770 (33.91%) | 2341 (37.08%) a | 244 (19.52%) a | 113 (28.91%) | 67 (36.02%) | 5 (17.25%) | |
| Education (y) (n = 8137) | 15.8 ± 2.9 | 16.20 ± 2.68 | 14.66 ± 3.09 a | 13.28 ± 4.26 a | 16.81 ± 2.68 a | 15.21 ± 2.35 | <.001 |
| Education (n = 8137) | <.001 | ||||||
| ≤12 years | 1397 (17.17%) | 854 (13.58%) a | 364 (29.12%) a | 153 (39.53%) a | 20 (10.99%) | 6 (20.69%) | |
| >12 years | 6740 (82.83%) | 5435 (86.42%) a | 886 (70.88%) a | 234 (60.47%) a | 162 (89.01%) | 23 (79.31%) | |
| MMSE (n = 6286) | 28.9 ± 1.4 | 29.04 ± 1.22 | 28.12 ± 1.87 a | 28.44 ± 1.82 a | 28.81 ± 1.25 a | 27.83 ± 1.75 a | <.001 |
| Depression (n = 8168) | <.001 | ||||||
| No | 7602 (93.7%) | 5838 (92.48%) a | 1195 (95.60%) a | 363 (93.08%) | 178 (95.70%) | 28 (96.55%) | |
| Yes | 566 (6.93%) | 475 (7.52%) a | 55 (4.40%) a | 27 (6.92%) | 8 (4.30%) | 1 (3.45%) | |
| Antidepressant (n = 7994) | <.001 | ||||||
| No | 6769 (84.68%) | 5089 (82.57%) a | 1152 (93.35%) a | 326 (84.46%) | 178 (97.80%) a | 24 (82.76%) | |
| Yes | 1225 (15.32%) | 1074 (17.43%) a | 82 (6.65%) a | 60 (15.54%) | 4 (2.20%) a | 5 (17.24%) | |
| VCS (n = 8168) | 1.6 ± 1.3 | 1.58 ± 1.29 | 1.89 ± 1.27 a | 1.70 ± 1.32 | 1.52 ± 1.32 | 2.28 ± 1.44 a | <.001 |
| APOE ε status (n = 7210) | <.001 | ||||||
| APOE ε4 − | 5133 (71.19%) | 4065 (71.68%) | 674 (65.06%) a | 249 (74.33%) | 130 (88.44%) a | 15 (71.43%) | |
| APOE ε4 + | 2077 (28.81%) | 1606 (28.32%) | 362 (34.94%) a | 86 (25.67%) | 17 (11.56%) a | 6 (28.57%) | |
| Follow‐up (y) (n = 8168) | 4.6 ± 3.4 | 4.68 ± 3.41 | 4.52 ± 3.27 | 3.83 ± 2.95 a | 3.94 ± 3.08 a | 2.62 ± 1.80 a | <.001 |
| Vital status (n = 8168) | <.001 | ||||||
| Alive | 6779 (82.99%) | 5122 (81.13%) a | 1089 (87.12%) a | 360 (92.31%) a | 180 (96.77%) a | 28 (96.55%) | |
| Dead | 1389 (17.01%) | 1191 (18.87%) a | 161 (12.88%) a | 30 (7.69%) a | 6 (3.23%) a | 1 (3.45%) | |
Abbreviations: AA, African American; AIAN, American Indian and Alaska Native; APOE ε+, apolipoprotein E ε4 allele; mean ± standard Deviation; MMSE, Mini‐Mental State Examination; nHW, non‐Hispanic White; VCS, Vascular Composite Score.
a
= group difference.