Table 2.
Factors associated with preference for on‐demand versus daily PrEP, after adjustment for site, sex and age group
| Characteristic | Category | Prefer daily | Prefer on‐demand | Total | Crude OR (95% CI) | p‐value | Adjusted OR (95% CI) | p‐value |
|---|---|---|---|---|---|---|---|---|
| Site | Cape Town | 146 (68%) | 68 (32%) | 214 | 0.16 (0.11, 0.22) | <0.001 | 0.15 (0.11, 0.22) | <0.001 |
| Johannesburg | 84 (46%) | 100 (54%) | 184 | 0.40 (0.28, 0.57) | 0.39 (0.28, 0.56) | |||
| Entebbe | 124 (25%) | 367 (75%) | 491 | Baseline | Baseline | |||
| Zimbabwe | 167 (42%) | 231 (58%) | 398 | 0.47 (0.35, 0.62) | 0.46 (0.35, 0.62) | |||
| Sex | Male | 225 (35%) | 422 (65%) | 647 | Baseline | <0.001 | Baseline | <0.001 |
| Female | 296 (46%) | 344 (54%) | 640 | 0.62 (0.50, 0.78) | 0.59 (0.47, 0.75) | |||
| Age group | 13–15 | 74 (53%) | 65 (47%) | 139 | 0.54 (0.38, 0.77) | 0.003 | 0.53 (0.36, 0.78) | 0.004 |
| 16–17 | 98 (43%) | 132 (57%) | 230 | 0.83 (0.62, 1.11) | 0.001 (trend) | 0.85 (0.62, 1.15) | 0.001 (trend) | |
| 18–24 | 349 (38%) | 569 (62%) | 918 | Baseline | Baseline | |||
| No. of partners, last 6 months | 0 | 141 (39%) | 222 (61%) | 363 | 1.06 (0.81, 1.40) | 0.41 | 0.69 (0.49, 0.97) | 0.02 |
| 1 | 200 (40%) | 296 (60%) | 496 | Baseline | 0.20 (trend) | Baseline | 0.85 (trend) | |
| 2 | 73 (37%) | 126 (63%) | 199 | 1.17 (0.83, 1.64) | 1.26 (0.87, 1.84) | |||
| 3 | 50 (46%) | 59 (54%) | 109 | 0.80 (0.53, 1.21) | 0.81 (0.51, 1.29) | |||
| 4 or more | 49 (45%) | 59 (54%) | 108 | 0.81 (0.54, 1.24) | 0.65 (0.41, 1.03) | |||
| Sex frequency past month | At least daily | 29 (59%) | 20 (41%) | 49 | 0.35 (0.20, 0.64) | <0.001 | 0.55 (0.29, 1.06) | 0.24 |
| 2–3 times a week | 108 (47%) | 120 (53%) | 228 | 0.57 (0.42, 0.78) | <0.001 (trend) | 0.72 (0.50, 1.05) | 0.04 (trend) | |
| Once a week | 89 (43%) | 117 (57%) | 206 | 0.68 (0.49, 0.94) | 0.95 (0.64, 1.39) | |||
| Once a month | 87 (41%) | 124 (59%) | 211 | 0.73 (0.53, 1.02) | 0.95 (0.66, 1.36) | |||
| Never | 184 (34%) | 358 (66%) | 542 | Baseline | Baseline | |||
| Last time had sex, how far in advance knew | <2 hours | 209 (46%) | 246 (54%) | 455 | Baseline | <0.001 | Baseline | 0.07 |
| 2–12 hours | 83 (41%) | 121 (59%) | 204 | 1.24 (0.89, 1.73) | <0.001 (trend) | 1.35 (0.94, 1.93) | 0.02 (trend) | |
| 13–24 hours | 34 (39%) | 53 (61%) | 87 | 1.32 (0.83, 2.12) | 1.09 (0.66, 1.81) | |||
| >24 hours | 76 (29%) | 183 (71%) | 259 | 2.05 (1.48, 2.83) | 1.56 (1.09, 2.22) | |||
| Age most recent partner | >5 years younger | 9 (64%) | 5 (36%) | 14 | 0.48 (0.15, 1.47) | <0.001 | 0.34 (0.10, 1.10) | 0.05 |
| 1–5 years younger | 91 (31%) | 205 (69%) | 296 | 1.93 (1.33, 2.81) | 1.25 (0.83, 1.90) | |||
| Same age | 91 (46%) | 106 (54%) | 197 | Baseline | Baseline | |||
| 1–5 years older | 135 (40%) | 206 (60%) | 341 | 1.31 (0.92, 1.87) | 1.40 (0.90, 2.17) | |||
| >5 years older | 66 (48%) | 71 (52%) | 137 | 0.92 (0.60, 1.43) | 0.94 (0.655 1.61) | |||
| Relationship, last partner | Regular partner | 336 (41%) | 494 (60%) | 830 | Baseline | 0.11 | Baseline | 0.09 |
| Casual partner | 61 (36%) | 107 (64%) | 168 | 1.19 (0.85, 1.68) | 1.11 (0.76, 1.62) | |||
| Transactional sex | 5 (83%) | 1 (17%) | 6 | 0.14 (0.02, 1.17) | 0.13 (0.01, 1.18) | |||
| HIV status recent partner | Negative | 227 (39%) | 357 (61%) | 584 | Baseline | 0.15 | Baseline | 0.05 |
| Positive | 4 (80%) | 1 (20%) | 5 | 0.16 (0.02, 1.43) | 0.16 (0.02, 1.58) | |||
| Don't know | 169 (41%) | 244 (59%) | 413 | 0.92 (0.71, 1.19) | 0.77 (0.57, 1.02) | |||
| Perceived chance of HIV next 3 months | No chance | 299 (36%) | 523 (64%) | 822 | Baseline | <0.001 | Baseline | 0.06 |
| Some chance | 160 (45%) | 194 (55%) | 354 | 0.69 (0.54, 0.89) | <0.001 (trend) | 0.77 (0.58, 1.01) | 0.006 (trend) | |
| Moderate chance | 47 (55%) | 39 (45%) | 86 | 0.47 (0.30, 0.74) | 0.64 (0.39, 1.03) | |||
| High chance | 15 (60%) | 10 (40%) | 25 | 0.38 (0.17, 0.86) | 0.50 (0.21, 1.20) | |||
| Would disclose PrEP to partner | No | 148 (36%) | 266 (64%) | 414 | Baseline | 0.03 | Baseline | 0.01 |
| Yes | 348 (42%) | 477 (58%) | 825 | 0.76 (0.60, 0.97) | 0.71 (0.55, 0.92) |