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. 2022 Aug 11;13:942178. doi: 10.3389/fphar.2022.942178

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Copyright © 2022 D'Ercole, Nistri, Pacini, Carotenuto, Santoro, Papini, Bathgate, Bani and Rovero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of RXFP1 signaling pathway activation. (A) cAMP generation in human monocytic THP-1 cells: both serelaxin (RLX) and peptide B7-33 induce a statistically significant elevation of cAMP, while none of the tested H1 peptides yielded a significant elevation of cAMP at any tested concentration. The adenylate cyclase activator forskolin (FK) was used to assess maximal cAMP yield. (B) ERK1/2 phosphorylation in mouse myofibroblasts: serelaxin induced a statistically significant increase in pERK1/2 at both 30 and 90 min, while none of the tested H1 peptides did. Values are mean ± SEM of 3 independent experiments. Significance of differences: ∗ p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.