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. 2022 Aug 11;4:943152. doi: 10.3389/ftox.2022.943152

FIGURE 1.

FIGURE 1

Decision tree applied in the 2 out of 3 (2o3) defined approach. In the 2o3 defined approach concordant predictions for two Key Event (KE) allow to classify a chemical as sensitiser or non-sensitiser. In case of discordant results, information on a third KE needs to be generated to conclude.