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. 2022 Aug 11;13:943574. doi: 10.3389/fimmu.2022.943574

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Copyright © 2022 Reitsema, Jiemy, Wekema, Boots, Heeringa, Huitema, Abdulahad, van Sleen, Sandovici, Roozendaal, Diepstra, Kwee, Dasgupta, Brouwer and van der Geest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFN-γ and IL-17 production by T cells in synovial fluid of patients with PMR. (A) Representative flow cytometric staining (left panel) and percentages (right panels) of CD4⁺IFN-γ⁺IL-17^- (T_H1), CD4⁺IFN-γ⁺IL-17⁺ (T_H1/T_H17) and CD4⁺IFN-γ^-IL-17⁺ (T_H17) T cells, and (B) CD8⁺IFN-γ⁺IL-17^- (T_C1), CD8⁺IFN-γ⁺IL-17⁺ (T_C1/T_C17) and CD8⁺IFN-γ^-IL-17⁺ (T_C17) T cells in peripheral blood (PB) and synovial fluid (SF) of 8 patients with PMR. Statistical significance by Wilcoxon signed rank test is indicated.