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. 2022 Aug 11;13:943574. doi: 10.3389/fimmu.2022.943574

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Copyright © 2022 Reitsema, Jiemy, Wekema, Boots, Heeringa, Huitema, Abdulahad, van Sleen, Sandovici, Roozendaal, Diepstra, Kwee, Dasgupta, Brouwer and van der Geest

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFN-γ and IL-17 expression by T cells in synovial tissue of patients with PMR. (A) Representative immunohistochemistry staining for IFN-γ (left panel) and IL-17 (right panel) in the synovial biopsy of a patient with PMR. Arrows indicate IL-17⁺ cells. (B) Semi-quantitative scoring for IFN-γ and IL-17 in bursa tissue biopsies of 11 patients with PMR. The scores of two independent investigators were averaged. (C) Representative immunofluorescence staining for colocalization of IFN-γ and CD3 (yellow) in the bursa tissue biopsy of a patient with PMR. CD3 (red) and IFN-γ (green) single staining are also shown together with DAPI counterstaining (blue). (D) Representative immunofluorescence staining for colocalization of IL-17 and CD3 (yellow) in the bursa tissue biopsy of a patient with PMR. CD3 (red) and IL-17 (green) single staining are also shown together with DAPI counterstaining (blue). Representative immunofluorescence images of two other patients are shown in Supplementary Figure S9 . Images are shown at 40x magnification.