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. 2022 Aug 23;219(10):e20220759. doi: 10.1084/jem.20220759

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© 2022 Kessler et al.

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Figure 1. — Patients with ANCA-associated vasculitis show increased cGAS activation and IFN-I signature. (A) cGAMP concentration in PBMCs isolated from healthy donors or patients with active anti-MPO-associated vasculitis (patient cohort I; Table S1). Each dot is an individual donor (n = 22 for healthy, n = 10 for MPO-vasculitis donors). Columns represent mean ± SEM. (B) GSEA in patients undergoing active anti-MPO-associated vasculitis (n = 21, patient cohort II; Table S2). (C) Heatmap of IFN-I pathway leading-edge gene expression levels in patients with active anti-MPO-associated vasculitis (MPO, n = 21) or in remission (Control, n = 47; patient cohort II). (D) Expression levels for selected ISGs from analysis in C. Asterisks indicate the significance level of unpaired t test (A and D) and familywise-error rate (B) *, P < 0.05; **, P < 0.01; ***, P < 0.001.