Figure 7.

Pharmacological inhibition of STING or JAK/STAT pathways ameliorates AAPV in mice. (A) Schematic representation of experiment with H151 STING inhibitor. (B–F) Weight change kinetics (B), hemorrhages in BALF (C and D), leukocyte infiltration (E), and lung injury score (F) in mice treated as in A. (G) Schematic representation of experiment with JAK1/2 inhibitor baricitinib. (H–J) Weight change (H), lung injury score (I), and hemorrhages in the BALF (J) of wild-type mice treated as in A. Each dot represents an individual mouse (D–F, I, and J). Shown are pooled data from two independent experiments with 5–12 mice/group (B–F), or 10–12 mice/group (H–J). Bar and line graphs show mean ± SEM. Asterisks indicate the significance level of unpaired t test (E, I, and J), one-way ANOVA Tukey’s multiple comparisons test (D and F), and two-way ANOVA with Šídák's multiple comparisons test (B and H). *, P < 0.05; **, P < 0.01.***, P < 0.001.