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. 2022 Aug 11;13:899384. doi: 10.3389/fgene.2022.899384

TABLE 3.

Univariate and multivariable Cox regression of TK1 expression for progression-free survival in PCa patients.

Characteristics Total (N) Univariate analysis Multivariate analysis
Hazard ratio (95% CI) p Value Hazard ratio (95% CI) p Value
Age 499
≤60 224 Reference
>60 275 1.302 (0.863-1.963) 0.208
T stage 492
T2 189 Reference
T3&T4 303 3.785 (2.140-6.693) <0.001 1.442 (0.690-3.017) 0.331
N stage 426
N0 347 Reference
N1 79 1.946 (1.202-3.150) 0.007 0.812 (0.463-1.423) 0.466
M stage 458
M0 455 Reference
M1 3 3.566 (0.494-25.753) 0.208
Gleason score 499
6&7&8 357 Reference
9&10 142 4.590 (3.038-6.934) <0.001 2.040 (1.160-3.588) 0.013
Primary therapy outcome 438
PD&SD&PR 97 Reference
CR 341 0.151 (0.099-0.231) <0.001 0.283 (0.161-0.499) <0.001
Residual tumor 468
R0 315 Reference
R1&R2 153 2.365 (1.566-3.570) <0.001 1.041 (0.609-1.781) 0.883
PSA (ng/ml) 442
<4 415 Reference
≥4 27 4.196 (2.095-8.405) <0.001 1.990 (0.894-4.432) 0.092
TK1 499 1.862 (1.506-2.302) <0.001 1.486 (1.119-1.975) 0.006