TABLE 4.
The correlations between TK1 and gene markers of immune cells in PCa and normal cells by TIMER.
| Description | Gene markers | Nonecor | p Value | Puritycor | p Value |
|---|---|---|---|---|---|
| CD8+T cell | CD8A | -0.039 | 0.383 | -0.010 | 0.832 |
| CD8B | -0.009 | 0.842 | -0.011 | 0.830 | |
| T cell (general) | CD3D | 0.062 | 0.165 | 0.088 | 0.074 |
| CD3E | 0.030 | 0.510 | 0.052 | 0.285 | |
| CD2 | 0.060 | 0.184 | 0.091 | 0.063 | |
| B cell | CD19 | 0.044 | 0.324 | 0.050 | 0.312 |
| CD79A | 0.141 | 0.216 | 0.129 | 0.274 | |
| Monocyte | CD86 | -0.001 | 0.997 | -0.031 | 0.794 |
| CD115(CSF1R) | -0.206 | * | -0.234 | * | |
| TAM | CCL2 | -0.086 | 0.451 | -0.076 | 0.520 |
| CD68 | 0.144 | 0.206 | 0.118 | 0.314 | |
| IL10 | 0.037 | 0.748 | 0.040 | 0.733 | |
| M1 macrophage | INOS(NOS2) | 0.083 | 0.469 | 0.070 | 0.551 |
| IRF5 | -0.184 | 0.105 | -0.213 | * | |
| COX2(PTGS2) | 0.215 | * | 0.231 | * | |
| M2 macrophage | CD163 | -0.080 | 0.484 | -0.081 | 0.491 |
| VSIG4 | -0.058 | 0.613 | -0.076 | 0.521 | |
| MS4A4A | -0.099 | 0.384 | -0.104 | 0.377 | |
| Neutrophils | CD66b (CEACAM8) | 0.188 | * | 0.186 | 0.112 |
| CD11b (ITGAM) | -0.121 | 0.286 | -0.155 | 0.187 | |
| CCR7 | -0.162 | 0.153 | -0.172 | 0.142 | |
| NK | KIR2DL1 | 0.058 | 0.612 | 0.008 | 0.949 |
| KIR2DL3 | -0.058 | 0.614 | -0.039 | 0.739 | |
| KIR2DL4 | 0.181 | 0.111 | 0.165 | 0.161 | |
| KIR3DL1 | -0.098 | 0.392 | -0.086 | 0.465 | |
| KIR3DL2 | 0.021 | 0.855 | -0.020 | 0.864 | |
| KIR3DL3 | 0.003 | 0.979 | 0.046 | 0.697 | |
| KIR2DS4 | -0.077 | 0.502 | -0.077 | 0.516 | |
| Dendritic cell | HLA-DPB1 | -0.149 | 0.189 | -0.146 | 0.213 |
| HLA-DQB1 | -0.102 | 0.371 | -0.098 | 0.407 | |
| HLA-DRA | -0.188 | * | -0.186 | * | |
| BDCA-1(CD1C) | -0.214 | 0.058 | -0.234 | 0.045 | |
| BDCA-4(NRP1) | 0.271 | ** | 0.297 | * | |
| CD11c | 0.090 | 0.428 | 0.026 | 0.823 | |
| Th1 | T-bet (TBX21) | -0.146 | 0.198 | -0.128 | 0.277 |
| STAT4 | 0.010 | 0.927 | 0.026 | 0.824 | |
| STAT1 | 0.310 | *** | 0.355 | *** | |
| IFN-γ(IFNG) | -0.010 | 0.928 | 0.045 | 0.706 | |
| TNF-α(TNF) | 0.074 | 0.518 | 0.083 | 0.483 | |
| Th2 | GATA3 | 0.311 | *** | 0.350 | *** |
| STAT6 | -0.262 | ** | -0.250 | ** | |
| IL13 | 0.219 | ** | 0.223 | ** | |
| Tfh | BCL6 | 0.108 | 0.343 | 0.102 | 0.388 |
| Th17 | STAT3 | 0.178 | 0.116 | 0.202 | 0.085 |
| IL17A | 0.178 | 0.116 | 0.183 | 0.119 | |
| Treg | FOXP3 | 0.145 | 0.202 | 0.136 | 0.246 |
| CCR8 | 0.032 | 0.781 | 0.024 | 0.836 | |
| STAT5B | -0.117 | 0.302 | -0.105 | 0.374 | |
| TGFβ(TGFB1) | 0.254 | ** | 0.260 | ** | |
| T cell exhaustion | PD-1(PDCD1) | -0.012 | 0.914 | 0.000 | 0.999 |
| CTLA4 | -0.082 | 0.472 | -0.096 | 0.415 | |
| LAG3 | 0.185 | 0.102 | 0.197 | 0.093 | |
| TIM3(HAVCR2) | 0.043 | 0.708 | 0.016 | 0.892 | |
| GZMB | 0.063 | 0.580 | 0.052 | 0.658 |
*<0.05, **<0.01, ***<0.001.