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Interactions of sorafenib with PKCη and MAPKAPK2
A. Binding curve of sorafenib with PKCη. B. Binding curve of sorafenib with MAPKAPK2. The predicted interactions of sorafenib with PKCη and MAPKAPK2 proteins were experimentally verified through MST experiments. MST-derived binding curves of NT647-labeled PKCη and MAPKAPK2 to sorafenib were plotted as a function of sorafenib concentration. Data are represented as mean ± SD (n = 2). MST, MicroScale thermophoresis.
