Table 3.

Interactions between kinase inhibitors and ERα

Drug	Scorepositive	Scorenegative	Scorepositive − Scorenegative	Docking score	Random chance	Binding affinity (mean ± SD)
Sunitinib	0.52	0.74	−0.22	−154.7	7%	14.7 ± 5.7 nM
Dasatinib	0.51	0.75	−0.24	−52.83	8%	1.2 ± 0.5 μM
Pazopanib	0.57	0.76	−0.19	−43.23	3%	3.2 ± 1.0 μM