Table 5.

Interactions between kinase inhibitors and CYPs.

Drug	Subtype	Docking score	IC50 (μM)
Dasatinib	CYP2E1	−194.61	>50
Dasatinib	CYP2A6	−100.57	35
Pazopanib	CYP1A2	−105.97	16

Note: These interactions are also reported in the FDA Orange Books [65], [66]. CYP, cytochrome 450; IC50, half maximal inhibitory concentration.