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. 2022 Aug 11;9:978366. doi: 10.3389/fcvm.2022.978366

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Copyright © 2022 Genovesi, Montelisciani, Viazzi, Giussani, Lieti, Patti, Orlando, Antolini, Salvi and Parati.

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Mediation analysis model with PWV as outcome, including HOMA-index and SUA as mediators (A), with SBP (B) and DBP (C) z-scores as outcome, including HOMA-index and SUA as mediators and with PWV as outcome including SUA and eGFR as mediators (D). SUA, serum uric acid; HOMA-index, homeostatic model assessment index; PWV, pulse wave velocity; eGFR, estimated glomerular filtration rate; SBP-z, systolic blood pressure z-score; DBP-z, diastolic blood pressure z-score. Continuous line, statistically significant; dotted line, not statistically significant; green line, direct effect; blue line, indirect effect.