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. 2022 Aug 11;9:978366. doi: 10.3389/fcvm.2022.978366

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Copyright © 2022 Genovesi, Montelisciani, Viazzi, Giussani, Lieti, Patti, Orlando, Antolini, Salvi and Parati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mediation analysis model with PWV as outcome, including HOMA-index, SUA, SBP (A) and DBP (B) z-scores as mediators. SUA, serum uric acid; HOMA-index, homeostatic model assessment index; PWV, pulse wave velocity; eGFR, estimated glomerular filtration rate; SBP-z, systolic blood pressure z-score; DBP-z, diastolic blood pressure z-score. Continuous line, statistically significant; dotted line, not statistically significant; green line, direct effect; blue line, partial indirect effect (one mediator); red line, partial indirect effect (two mediators). Overall indirect effect (with SBP z) = 0,100 p < 0,001. Overall indirect effect (with DBP z) = 0,084 p < 0,001.