Table 4.
The subgroup analyses of MELD-XI score and 3-year all-cause mortality of heart failure.
| Group | High MELD-XI† | Low MELD-XI† | HR (95%CI) | P-value | P for interaction | HRadjusted (95%CI) | P for interaction | |
|---|---|---|---|---|---|---|---|---|
| All | 58/144 | 39/256 | 3.19 (2.11–4.82) | <0.001 | 1.79 (1.09–2.91) | 0.020 | ||
| Age | 0.286 | |||||||
| <65 | 6/51 | 7/28 | 3.60 (2.30–5.63) | <0.001 | 0.38 (0.09–2.47) | 0.193 | 0.184 | |
| ≥65 | 51/116 | 33/205 | 1.80 (0.60–5.35) | 0.294 | 2.17 (1.28–3.67) | 0.004 | ||
| Gender | 0.286 | |||||||
| Male | 33/93 | 13/113 | 4.11 (2.07–8.13) | <0.001 | 2.33 (1.05–5.14) | 0.037 | 0.967 | |
| Female | 25/51 | 26/143 | 3.20 (1.85–5.56) | <0.001 | 1.58 (0.82–3.06) | 0.175 | ||
| Types of heart failure | 0.218 | |||||||
| HFrEF | 10/30 | 9/49 | 1.66 (0.68–4.09) | 0.269 | 1.26 (0.43–3.69) | 0.668 | 0.534 | |
| HFmrEF | 8/21 | 5/34 | 2.59 (0.85–7.94) | 0.095 | 1.52 (0.43–5.34) | 0.514 | ||
| HFpEF | 40/93 | 25/173 | 4.12 (2.46–6.89) | <0.001 | 1.59 (0.82–3.09) | 0.174 | ||
| NYHA grade | 0.966 | |||||||
| II | 6/28 | 8/99 | 2.46 (0.85–7.11) | 0.095 | 0.42 (0.07–2.56) | 0.346 | 0.868 | |
| III | 31/80 | 22/129 | 2.95 (1.68–5.17) | <0.001 | 1.91 (1.00–3.64) | 0.051 | ||
| IV | 21/36 | 9/36 | 2.66 (1.21–5.83) | 0.015 | 2.01 (0.79–5.10) | 0.141 | ||
| Chronic kidney disease | 0.049 | |||||||
| Yes | 28/65 | 4/9 | 1.04 (0.37–2.97) | 0.941 | 0.68 (0.22–2.15) | 0.516 | 0.038 | |
| No | 30/79 | 35/247 | 3.30 (2.01–5.42) | <0.001 | 1.88 (1.06–3.35) | 0.032 | ||
| Hepatopathy | 0.726 | |||||||
| Yes | 8/14 | 3/12 | 2.20 (0.58–8.35) | 0.248 | 1.36 (0.17–10.04) | 0.791 | 0.229 | |
| No | 50/130 | 36/244 | 3.15 (2.04–4.87) | <0.001 | 1.65 (0.98–2.77) | 0.059 | ||
| Heart valve disease | 0.669 | |||||||
| Yes | 29/68 | 17/94 | 3.53 (1.89–6.60) | <0.001 | 1.98 (0.95–4.16) | 0.070 | 0.908 | |
| No | 29/76 | 22/162 | 2.89 (1.66–5.04) | <0.001 | 1.39 (0.72–2.71) | 0.330 | ||
| Atrial fibrillation | 0.901 | |||||||
| Yes | 22/65 | 22/122 | 2.92 (1.69–5.05) | <0.001 | 2.62 (1.37–5.03) | 0.004 | 0.796 | |
| No | 22/65 | 17/144 | 3.21 (1.70–6.05) | <0.001 | 0.97 (0.40–2.35) | 0.951 | ||
| Hypertension | 0.530 | |||||||
| Yes | 35/89 | 25/171 | 3.55 (2.10–6.02) | <0.001 | 1.73 (0.88–3.41) | 0.115 | 0.373 | |
| No | 23/55 | 14/85 | 2.62 (1.35–5.09) | 0.005 | 1.75 (0.81–3.80) | 0.158 | ||
| Diabetes mellitus | 0.097 | |||||||
| Yes | 15/43 | 14/77 | 1.96 (0.95–4.07) | 0.07 | 0.85 (0.33–2.34) | 0.747 | 0.121 | |
| No | 43/101 | 25/179 | 3.94 (2.37–6.55) | <0.001 | 2.19 (1.21–3.96) | 0.010 | ||
| Smoking history | 0.529 | |||||||
| Yes | 22/59 | 11/80 | 4.09 (1.88–8.91) | <0.001 | 2.44 (0.90–6.62) | 0.081 | 0.956 | |
| No | 36/256 | 28/176 | 2.94 (1.87–4.81) | <0.001 | 1.75 (0.99–3.11) | 0.056 |
CI, confidence interval; HR, hazard ratio.
*Covariates used for adjustment: DBP, RDW-CV, BUN, NT-proBNP, Prealbumin, Na+.
†
Death events/ patients.