FIGURE 2.

(Central Illustration): (A) Main clinical and radiographic findings in ECD. (B) Clinical and radiographic findings in specific subgroups of ECD. Characteristics of the general adult population, the pediatric population, patients with associated hematologic disorder, in mixed histiocytosis and the respective most frequently associated genetic mutations reported in the literature. (C) Clinical and radiographic findings of ECD in patients with mutation of KRAS, MAP2K1, PIK3CA, NRAS, and BRAF. Note: In (B,C), clinical and radiological features of the specific subgroups were depicted transparent if they were never reported in the literature. Instead, they were reported with a blue halo if there was a statistically significant low frequency involvement; a white halo if there was a normal frequency involvement; and finally with a red halo if there was a statistically significant common involvement in the respective group.