Table 3.
Multivariate time-varying Cox regression analysis for hepatocellular carcinoma and death/transplantation in entire cohort
| Variable |
Hepatocellular carcinoma
|
Decompensation
|
Death/transplantation
|
|||
|
aHR (95%CI)
|
P
value
|
aHR (95%CI)
|
P
value
|
aHR (95%CI)
|
P
value
|
|
| Model 1 | ||||||
| Untreated group | Reference | - | Reference | - | Reference | - |
| IBT group | 0.47 (0.28-0.80) | 0.005 | 0.16 (0.08-0.33) | < 0.001 | 0.28 (0.18-0.43) | < 0.001 |
| DAA group | 0.58 (0.35-0.96) | 0.035 | 0.12 (0.03-0.33) | < 0.001 | 0.19 (0.10-0.35) | < 0.001 |
| Age, yr | 1.06 (1.03-1.08) | < 0.001 | 1.00 (0.98-1.03) | 0.805 | 1.05 (1.03-1.06) | < 0.001 |
| Male sex | 2.50 (1.37-4.55) | 0.003 | - | - | 1.70 (1.24-2.33) | < 0.001 |
| HCV genotype | - | - | - | - | ||
| 2 | Reference | - | ||||
| 1 | 2.25 (1.45-3.48) | < 0.001 | ||||
| Others/unknown | 1.72 (0.66-4.48) | 0.266 | ||||
| Cirrhosis | 3.81 (2.38-6.10) | < 0.001 | 9.26 (4.03-21.03) | < 0.001 | 1.88 (1.34-2.64) | < 0.001 |
| Ever smoker | 1.47 (0.82-2.66) | 0.192 | - | - | - | - |
| Alcohol consumption | - | - | - | - | ||
| None | Reference | - | ||||
| Social | 1.20 (0.73-1.98) | 0.473 | ||||
| Significant | 2.20 (1.14-4.24) | 0.027 | ||||
| BMI, kg/m2 | - | - | - | - | 0.94 (0.89-0.99) | 0.019 |
| Diabetes mellitus | 0.96 (0.59-1.56) | 0.872 | - | - | 1.12 (0.77-1.62) | 0.563 |
| Albumin, g/dL | 0.71 (0.44-1.15) | 0.162 | 0.35 (0.20-0.63) | < 0.001 | 0.36 (0.25-0.51) | < 0.001 |
| Total bilirubin, mg/dL | 0.95 (0.80-1.12) | 0.568 | 1.03 (0.98-1.08) | 0.264 | - | - |
| PT, INR | 2.66 (1.13-6.24) | 0.025 | 3.32 (1.08-10.19) | 0.036 | 2.34 (1.06-5.16) | 0.034 |
| AFP, log10 ng/dL | 2.12 (1.48-3.05) | < 0.001 | 1.54 (0.95-2.51) | 0.08 | 1.29 (0.94-1.77) | 0.112 |
| Model 2 | ||||||
| Untreated or no SVR | Reference | - | Reference | - | Reference | - |
| SVR | 0.41 (0.26-0.65) | < 0.001 | 0.10 (0.04-0.29) | < 0.001 | 0.26 (0.17-0.39) | < 0.001 |
| Age, yr | 1.06 (1.04- 1.08) | < 0.001 | 1.02 (0.99-1.04) | 0.152 | 1.06 (1.04-1.07) | < 0.001 |
| Male sex | 2.50 (1.38-4.54) | 0.003 | - | - | 1.68 (1.23-2.30) | 0.001 |
| HCV genotype | - | - | - | - | ||
| 2 | Reference | - | ||||
| 1 | 2.25 (1.45-3.48) | < 0.001 | ||||
| Others/unknown | 1.57 (0.60-4.09) | 0.359 | ||||
| Cirrhosis | 3.75 (2.35-6.01) | < 0.001 | 7.54 (3.32-17.15) | < 0.001 | 1.72 (1.23-2.41) | 0.002 |
| Ever smoker | 1.53 (0.85-2.75) | 0.156 | - | - | - | - |
| Alcohol consumption | - | - | - | - | ||
| None | Reference | - | ||||
| Social | 1.24 (0.75-2.04) | 0.397 | ||||
| Significant | 2.69 (1.40-5.16) | 0.003 | ||||
| BMI, kg/m2 | - | - | - | - | 0.94 (0.89-0.99) | 0.024 |
| Diabetes mellitus | 0.99 (0.61-1.61) | 0.959 | - | - | 1.10 (0.76-1.60) | 0.612 |
| Albumin, g/dL | 0.76 (0.47-1.20) | 0.238 | 0.42 (0.24-0.71) | 0.001 | 0.42 (0.30-0.60) | < 0.001 |
| Total bilirubin, mg/dL | 0.96 (0.81-1.13) | 0.624 | 1.03 (0.99-1.08) | 0.156 | - | - |
| PT, INR | 2.53 (1.02-6.28) | 0.044 | 4.42 (1.48-13.20) | 0.008 | 2.69 (1.22-5.92) | 0.014 |
| AFP, log10 ng/dL | 2.10 (1.46-3.02) | < 0.001 | 1.48 (0.90-2.44) | 0.12 | 1.17 (0.86-1.60) | 0.32 |
Total number of patients, 2197; number of hepatocellular carcinomas, 113; number of deaths, 202; number of transplantations, 4; number of decompensations, 69. AFP: Alpha-feto protein; aHR: Adjusted hazard ratio; BMI: Body mass index; CI: Confidence interval; DAA: Direct acting antivirals; HCV: Hepatitis C virus; IBT: Interferon-based therapy; PT: Prothrombin time; SVR: Sustained virologic response.