Table 1.

Summary of baseline characteristics of the prevalence of H. pylori infection in patients with and without BE.

First author	Country	Study design	BE on endoscopy		Prevalence of H. pylori infection		Methods for detection of H. pylori	Biopsy sites for detecting H. pylori	Diagnostic criteria for BE	Diagnostic timing of BE	Age and gender matched between 2 groups	Exclusion criteria for participants
			BE	No BE	BE	No BE						History of H. pylori eradication therapy	Using PPIs within at least 2 weeks before detection of H. pylori infection
Turner et al. 18	USA	Cross-sectional	52186	1207207	2332/ 52186	126351/ 1207207	H	Antral, corpus, and angus	IM	NA	No	No	No
Zhang et al. 19	China	Case-control	40	40	15/40	23/40	H, R	Esophageal and antral	CM	NA	No	No	No
Xu et al. 20	UK	Cross-sectional	38	202	3/38	34/202	R, S	NA	IM	NA	No	No	No
Tan et al. 21	USA	Cross-sectional	329	1856	68/329	606/ 1856	H	Antral, corpus, and cardia	IM	Previously	No	No	No
Chen et al. 22	China	Case-control	161	644	42/148	261/588	R	Antral	IM	NA	Yes	No	Yes
Dore et al. 23	Italy	Cross-sectional	133	1772	49/131	669/ 1772	H, R, U	Antral and corpus	IM	Newly	No	No	Yes
Rubenstein et al. 12	USA	Case-control	150	177	25/150	46/177	S	NA	IM	Newly	No	No	No
Sonnenberg et al. 24	USA	Cross-sectional	2510	76475	144/ 2510	9356/ 76475	H	Antral, corpus, and angus	IM	Previously	No	No	No
Abe et al. 16	Japan	Case-control	36	108	4/36	80/108	H, S, R	Antral, corpus	CM	Newly	Yes	Yes	Yes
Rajendra et al. 25	Malaysia	Case-control	55	53	29/55	32/53	H, S, R	Antral, corpus, and cardia	IM	Previously	No	Yes	Yes
§ lnomata et al. 17	Japan	Case-control	36	80	3/36	57/80	H, S, R	Antral, corpus	IM	NA	No	Yes	Yes
Loffeld et al. 26	Netherlands	Cross-sectional	307	5341	55/179	1550/ 3975	H, C	Antral	NA	Previously	No	No	No
Rajendra et al. 27	Malaysia	Case-control	123	1741	46/123	604/ 1741	H, R	Antral and corpus	IM	NA	No	Yes	Yes
Ackermark et al. 28	Netherlands	Cross-sectional	51	62	21/51	39/62	S	NA	IM	NA	No	No	No
Laheij et al. 29	Netherlands	Cross-sectional	23	528	6/23	281/528	H, C, R	Antral and corpus	CM	NA	No	Yes	No
Rugge et al. 30	Italy	Case-control	53	53	19/53	36/53	H, S, P	Antral, corpus, and incisural	IM	NA	Yes	Yes	Yes
Vaezi et al. 31	USA	Case-control	83	60	28/83	25/60	H, S	Antral, corpus	CM	Previously	No	Yes	No
Loffeld et al. 32	Netherlands	Cross-sectional	36	454	14/36	248/454	H, S, R, C	Antral	CM	Newly	No	Yes	Yes
Vieth et al. 33	Germany	Case-control	1054	712	562/ 1054	468/712	H	Antral and corpus	IM	Previously	No	No	No
Kiltz et al. 34	Germany	Case-control	35	320	8/35	91/320	R, S	Antrum and corpus	CM	Previously	No	Yes	No
Vicari et al. 35	USA	Case-control	48	57	15/48	26/57	H, S	Antral, fundus, and cardia	CM	Previously	No	No	No
Werdmuller et al. 36	Netherlands	Case-control	13	399	3/13	204/399	H, R, C, S	Antral	NA	NA	No	No	No
Newton et al. 37	UK	Case-control	16	25	4/16	9/25	H, R	Antral and fundus	CM	Previously	No	No	Yes
Paull et al. 38	USA	Case-control	26	26	10/26	11/26	H	Gastric and esophageal	CM	Previously	Yes	No	No

^§Study only in the analysis for BE segment length.

BE, Barrett’s esophagus; C, culture; CM, columnar metaplasia; H, histology; IM, intestinal metaplasia; PCR, polymerase chain reaction; PPIs, proton pump inhibitors; S, serology; SA, stool antigen; R, rapid urease test; U, urea breath test.