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. 2022 Aug 11;10:883118. doi: 10.3389/fbioe.2022.883118

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Copyright © 2022 Wang, Zhang, Zhao, Yu, Wang, Liu, Cheng, Shi, He, Xia and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scutellarin alleviates the degeneration of IVD in a rat IVDD model. (A–J) The expression levels of iNOS, COX-2, ADAMTS-5, MMP-13, and NLRP3 in IVD tissues from the con group (n = 5), needle puncture + PBS injection group (n = 5) and needle puncture + scutellarin injection group (n = 5) were detected by immunohistochemistry (scale bar: 100 μm). (K,L) The expression levels of cleaved caspase-3 in IVD tissues from each indicated group were assayed by immunofluorescence staining (scale bar: 100 μm). Each experiment was performed three times independently. (*p < 0.05, **p < 0.01, ***p < 0.001).