TABLE 3.

The roles of miR-21-5p in lung disease.

Author	Disease	Target/pathway	Role	Expression	Reference
Zhou	NSCLC	—	Biomarker	↑	Zhou et al. (2022)
Yan	NSCLC	TGF-βI	Induce cell proliferation	↑	Yan et al. (2018)
Tang	NSCLC	SMAD7	Boost NSCLC progression	↑	Tang et al. (2021)
Song	NSCLC	—	Decrease radiosensitivity	↑	Song et al. (2017)
Wu	HILI	SKP2/Nr2f2/C/EBPα axis	Alleviate HILI	—	Wu et al. (2022)
Qi	HILI	MAP2K3	Reduce cellular apoptosis	—	Qi et al. (2021)
Liu	HILI	PGAM5	Regulate hyperoxia-induced mitophagy and mitochondrial dysfunction	—	Liu et al. (2020)
Qin	Hyperoxic acute lung injury	PTEN/AKT	Inhibit apoptosis of AEC II cells	—	Qin et al. (2019)
Wang	PF	TGF-β1/SMAD and MAPK/AP-1 signaling pathways	Alleviate PF	—	Wang et al. (2018)
Ren	Lung cancer	PTEN, PDCD4, and RECK	Promote lung cancer development	—	Ren et al. (2019)
Li	Lung ischemia/reperfusion injury	PTEN and PDCD4	Alleviate lung ischemia/reperfusion injury	—	Li et al. (2019)