TABLE 4.

The roles of let-7d-5p in lung disease.

Author	Disease	Target/pathway	Role	Expression	Reference
Chen; Kumar; Mendes-Silva	Alzheimer’s diseaseAlzheimer’s disease	—	—	↓	Kumar et al. (2013); Mendes-Silva et al. (2016); Chen et al. (2018)
Liguori	Amyotrophic lateral sclerosis	—	—	↓	Liguori et al. (2018)
Sun	Necrotizing enterocolitis of neonatal rats	LGALS3-dependent TLR4/NF-κB signaling pathway	Anti-inflammatory properties and inhibited intestinal epithelial cell apoptosis	—	Sun et al. (2020)
Bagnato; Min	PF	—	—	↓	Min et al. (2016); Bagnato et al. (2017)
Gasparini; Kumar	NSCLC	—	Biomarker	↓	Gasparini et al. (2015); Kumar et al. (2020)
Gan	Lung cancer	NAP1L1	Repress angiogenesis	↓	Gan et al. (2022)
Ideozu	cystic fibrosis	—	—	↑	Ideozu et al. (2019)
Min	lung cysts/pneumothorax presentation of Birt-Hogg-Dubé Syndrome	—	—	↑	Min et al. (2020)
Tasena	COPD	—	—	↑	Tasena et al. (2018)
Gao	PF	TGF-ßRI	Mitigate PF	—	Gao et al. (2020)