TABLE 7.
The roles of miR-29b-3p in lung disease.
| Author | Disease | Target/pathway | Role | Expression | Reference |
|---|---|---|---|---|---|
| Deng; He | Tissue fibrosis (including heart, liver, lung and kidney) | Binding to the 3ʹUTR | Inhibit collagen synthesist | — | He et al. (2013); Deng et al. (2017) |
| Liang; Xue | Cardiac fibrosis | TGF-β1/SMAD pathway | — | — | Liang et al. (2019); Xue et al. (2020) |
| Gong; Tao | Liver fibrosis | STAT3 | Repress collagenous fibrosis | ↓ | Tao et al. (2018); Gong et al. (2020) |
| Lu | Liver fibrosis | TGF-β1 | Activate COL1A1 expression | — | Lu et al. (2017) |
| Mullenbrock; Cushing; Pandit | PF | TGF-β1/SMAD pathway | Downregulate miR-29b and promote PF | ↓ | Cushing et al. (2011); Pandit et al. (2011); Cushing et al. (2015); Mullenbrock et al. (2018) |
| Wan | PF | — | Suppress fibroblast proliferation and decrease the level of hydroxyproline | — | Wan et al. (2020) |