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. 2022 Aug 6;64:101564. doi: 10.1016/j.molmet.2022.101564

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Distribution of KLB⁺/Vglut2⁺ neurons in the CNS. (A) Schematic representation of the generation of KLB-Cre; Vglut-FLP; Ai65-tdTomato triple-knockin mice. CAG, CAG promoter coding sequence; FRT, FRT sequence; LoxP, LoxP sequence; STOP, stop codons; tdtomato, tdtomato reporter sequence; WPRE, gene enhancer sequence; polyA, polyadenylation. (B–H) Fluorescent images of brain regions in KLB-Cre; Vglut-FLP; Ai65-tdTomato triple-knockin mice including the (B) paraventricular nucleus (PVN), (C) arcuate nucleus (ARC), (D) ventromedial hypothalamus (VMH), (E) dorsomedial hypothalamus (DMH), (F) lateral hypothalamus (LH), (G) ventral premammillary nucleus (PMv), (H) basolateral amygdala (BLA), and (I) area postrema (AP) and nucleus of the solitary tract (NTS).