TABLE 3.
Nervous system functions enriched among DDE DMR-associated genes from discovery and validation data sets.
| Nervous system development and functions (discovery) | p-value* | Molecules |
|---|---|---|
| Development of central nervous system | 3.71E-06 | ANKLE2, ASIC2, ATOH1, CNTN6, CNTNAP2, EML1, GRIK1, GSK3B, HGF, JARID2, MBP, MYO16, PAX6, PDGFC, PROX1, TRAPPC9 |
| Synaptic transmission | 1.22E-03 | ASIC2, GRIA1, GRIK1, GRIK2, GRM5, MBP, NRG3, RIT2, SLC6A1, SYT1 |
| Recognition of neurons | 2.23E-03 | NTM, OPCML |
| Outgrowth of neurites | 3.11E-03 | GFRA2, GSK3B, HGF, mir-124, SHC1, SLIT2, TGFA |
| Guidance of axons | 3.88E-03 | DOK5, GFRA2, IRS2, NRXN3, NTN4, SHC1, SLIT2, UNC5A |
| Generation of nervous tissue cell lines | 7.17E-03 | MYT1L, RMST |
| Outgrowth of axons | 1.06E-02 | HGF, SLIT2 |
| Formation of brain | 1.83E-02 | CNTNAP2, EML1, GSK3B, HGF, MYO16, TRAPPC9 |
| Nervous system development and functions (validation) | p-value* | Molecules |
| Recognition of neurons | 2.50E-03 | NTM, OPCML |
| Outgrowth of neurites | 4.23E-03 | BMP4, ITGA1, ITGB1, mir-10, TGFA, TIAM1, WNT3A |
| Proliferation of neuronal cells | 5.08E-03 | BMP4, ITGA1, ITGB1, JAG1, mir-10, TGFA, TIAM1, WNT3A |
| Neurotransmission | 9.48E-03 | CBLN1, DTNA, GPR176, GRM5, KCNQ1, MBP, MYH14, PSEN-1, SYT1 |
| Quantity of neuroepithelial cells | 1.18E-02 | BMP4, BMP6 |
*Fisher exact p-value indicating the probability that the described function is not enriched among the indicated genes based on the reference set of genes in the IPA knowledgebase.