TABLE 5.
Differential methylation of SNORD115-30 and SNORD115-37 by DDE tertile validated by pyrosequencing analyses.
SNORD115-30 a | Average | |||||||
---|---|---|---|---|---|---|---|---|
Tertile | Pos. 1 | Pos. 2 | Pos. 3 | Pos. 4 | Pos. 5 | Pos. 6 | Pos. 7 | All positions |
First | 28.98 | 30.76 | 34.31 | 33.49 | 37.26 | 44.31 | 30.56 | 34.24 |
Third | 33.82 | 35.65 | 39.14 | 37.78 | 39.80 | 47.28 | 38.13 | |
Difference (third-first) | 4.84 | 4.89 | 4.82 | 4.30 | 2.54 | 2.97 | 2.89 | 3.89 |
SNORD115-37 b | Average | |||||||
---|---|---|---|---|---|---|---|---|
Tertile | Pos. 1 | Pos. 2 | Pos. 3 | Pos. 4 | All positions | |||
First | 41.12 | 36.29 | 33.84 | 41.63 | 38.22 | |||
Third | 45.86 | 41.88 | 39.41 | 46.01 | 43.29 | |||
Difference (third-first) | 4.74 | 5.59 | 5.57 | 4.38 | 5.07 |
Methylation was quantified at 7 specific positions in the SNORD115-30 DMR.
Methylation was quantified at 4 specific positions in the SNORD115-37 DMR.