Figure 4.

Verhoeff-Van Gieson- and hematoxylin and eosin-stained images of iliofemoral arteries from a pig injury model

The pig arteries were subject to endothelial denudation using a angioplasty balloon catheter, treated with Apt 14 (500 nM), NSC (500 nM) or saline via a perfusion catheter and harvested at 14 days after treatment. (A–F) Neointimal growth is marked by blue double-headed arrows. The internal elastic lamina is marked by black arrows. (G) Percent stenosis graph based on morphometric analysis of the Apt 14-, NSC-. and saline (control)-treated arteries. Data were analyzed by one-way ANOVA with Tukey post tests. ∗p < 0.05, ∗∗p < 0.01. n = 4.