Table 2. Two-sample Mendelian randomization estimations showing the effect of lipids on GSD.
| Exposure | Methods | Odds ratioa | 95% CI | P value | Ph | Q-statistics | |
|---|---|---|---|---|---|---|---|
| Lower limit | Upper limit | ||||||
| LDLC | IVW | 0.996 | 0.993 | 0.998 | 5.46E−04 | 9.06E−03 | 64.1 |
| MR-Egger | 0.995 | 0.992 | 0.999 | 7.97E−03 | 7.33E−03 | 63.8 | |
| Weighted median | 0.997 | 0.994 | 1.000 | 4.25E−02 | – | – | |
| Simple median | 0.997 | 0.993 | 1.001 | 1.06E−01 | – | – | |
| MR-Egger interceptb | 0.0001 | −0.0002 | 0.0003 | 6.57E−01 | – | – | |
| HDLC | IVW | 0.999 | 0.996 | 1.003 | 7.31E−01 | 2.76E−04 | 102.6 |
| MR-Egger | 0.997 | 0.989 | 1.004 | 3.51E−01 | 2.82E−04 | 101.2 | |
| Weighted median | 0.997 | 0.993 | 1.002 | 2.48E−01 | – | – | |
| Simple median | 0.998 | 0.993 | 1.003 | 4.06E−01 | – | – | |
| MR-Egger interceptb | 0.0002 | −0.0002 | 0.0005 | 3.77E−01 | – | – | |
| Triglycerides | IVW | 0.997 | 0.994 | 1.001 | 1.46E−01 | 3.79E−01 | 35.9 |
| MR-Egger | 0.993 | 0.987 | 0.999 | 2.98E−02 | 4.70E−01 | 32.9 | |
| Weighted median | 0.998 | 0.993 | 1.003 | 4.17E−01 | – | – | |
| Simple median | 1.003 | 0.996 | 1.009 | 4.39E−01 | – | – | |
| MR-Egger interceptb | 0.0001 | 0.0000 | 0.0005 | 9.45E−02 | – | – | |
| Hepatic steatosis | IVW | 0.994 | 0.985 | 1.003 | 2.06E−01 | 4.63E−03 | 8.0 |
| Histologic NAFLD | IVW | 0.993 | 0.984 | 1.003 | 1.53E−01 | 8.88E−03 | 6.8 |
a, odds ratio per 1 SD increase; b, regression coefficient (95% CI). GSD, gallstone disease; CI, confidence interval; LDLC, low-density lipoprotein cholesterol; HDLC, high-density lipoprotein cholesterol; NAFLD, non-alcoholic fatty liver disease; Ph, P value for heterogeneity; SD, standard deviation; IVW, inverse variance-weighting; MR, Mendelian randomization.