Table 3. Mendelian randomization estimations showing the effect of lipid profiles on GSD in male.
| Exposure | Methods | Odds ratioa | 95% CI | P value | Ph | Q-statistics | |
|---|---|---|---|---|---|---|---|
| Lower limit | Upper limit | ||||||
| LDLC | IVW | 0.995 | 0.991 | 0.998 | 3.50E−03 | 8.25E−02 | 52.9 |
| MR-Egger | 0.994 | 0.990 | 0.999 | 1.82E−02 | 6.90E−02 | 52.8 | |
| Weighted median | 0.993 | 0.989 | 0.998 | 6.69E−03 | – | – | |
| Simple median | 0.991 | 0.985 | 0.998 | 6.91E−03 | – | – | |
| MR-Egger interceptb | 0.0001 | −0.0002 | 0.0003 | 7.51E−01 | – | – | |
| HDLC | IVW | 1.000 | 0.997 | 1.004 | 9.75E−01 | 4.05E−02 | 78.1 |
| MR-Egger | 0.998 | 0.992 | 1.004 | 4.53E−01 | 4.14E−02 | 76.8 | |
| Weighted median | 1.000 | 0.995 | 1.005 | 9.16E−01 | – | – | |
| Simple median | 1.000 | 0.995 | 1.006 | 9.62E−01 | – | – | |
| MR-Egger interceptb | 0.0001 | −0.0001 | 0.0004 | 3.34E−01 | – | – | |
| Triglycerides | IVW | 1.000 | 0.997 | 1.004 | 9.72E−01 | 4.47E−01 | 34.4 |
| MR-Egger | 0.998 | 0.993 | 1.003 | 4.67E−01 | 4.48E−01 | 33.4 | |
| Weighted median | 1.000 | 0.995 | 1.006 | 8.63E−01 | – | – | |
| Simple median | 1.003 | 0.996 | 1.010 | 3.60E−01 | – | – | |
| MR-Egger interceptb | 0.0001 | −0.0001 | 0.0004 | 3.18E−01 | – | – | |
a, odds ratio per 1 SD increase; b, regression coefficient (95% CI). GSD, gallstone disease; CI, confidence interval; LDLC, low-density lipoprotein cholesterol; HDLC, high-density lipoprotein cholesterol; Ph, P value for heterogeneity; SD, standard deviation; IVW, inverse variance-weighting; MR, Mendelian randomization.