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. 2022 Aug 25;22:707. doi: 10.1186/s12879-022-07694-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Plasma metabolomic analysis for the SPPT patients, SNPT patients and controls. A Heatmap showing 103 differential abundant metabolites (DAMs, VIP > 1, p < 0.05) among the three groups. The colored bar above the heatmap represent the SPPT (red), SNPT (orange) and Ctrl (green) samples. The color key indicates the scaled expression levels of the 103 metabolites for the three groups. B Venn diagram showing the differential metabolites among the three groups. C Pie chart showing the chemical classification of the 103 significantly differentially abundant metabolites according to the HMDB database