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. 2022 Aug 11;13:949835. doi: 10.3389/fphar.2022.949835

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Copyright © 2022 Li, Peng, Yu, Xu, Han, Yang, Li, Hu, Liu, Yang, Xu, Chen, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHA activated ferroptosis in vivo. (A) Obvious expression of CD11b in the tumor grafts indicated the infiltration of macrophages. Induction of macrophages’ ferroptosis, which was evidenced by prominent COX-2 and reduced GPX4 expression, was analyzed by IHC staining. (B,C) Iron ions in the tumor grafts were measured using the PGSK probe. Decreased fluorescence of PGSK indicated elevated iron ions. Geometric means were applied to quantify the MFI. Values were means ± SD (n = 3, *p < 0.05).