Table 3.
Inhibitory effects on the expression of fascin-1 of different compounds in NSCC and NPC.
| Cancer Type | Compound | Experimental object | Outcomes | Refs. |
|---|---|---|---|---|
| NSCC | G2 | H1650, A549 H292, H23, LLC |
Inhibited cell growth and migration Inhibited the expression of YAP1 and PFKFB3 |
(60) |
| BL6 mice, nude mice | Reduced the tumor burden Improved the survival |
|||
| Sevoflurane | A549 | Reduced Proliferation rate and hypoxia-induced migration ability Down-regulation of HIF-1α expression |
(69) | |
| Sevoflurane | A549 | Reduced Proliferation rate and migration ability Reducing the levels of p38 MAPK phosphorylation |
(70) | |
| PCAIs | NCI-H1299 | Decreased in cell invasion | (71) | |
| NPC | Thiostrepton | C666-1, NP69 | Repressed the migration ability | (72) |