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. 2022 Jun 24;9(24):2201614. doi: 10.1002/advs.202201614

Figure 2.

Figure 2

OxPt/SN38 transfers Chol‐SN38 to LDL. Integrated binding heats upon injection of a) Chol‐SN38 into an LDL or albumin solution, b) OxPt/SN38 into an LDL or albumin solution, and c) Chol‐SN38 micelle or OxPt NCP without cholesterol into an LDL solution by ITC. d) The PMF for transferring SN38 (red line) and Chol‐SN38 (blue line) from bulk water to the lipid core of an LDL slice from MD simulations. The plots are superimposed onto a snapshot of an equilibrated LDL slice. e) Time‐dependent binding of SN38 or Chol‐SN38 to LDL and transfer of Chol‐SN38 from OxPt/SN38 to LDL in rat plasma. f) Concentration‐dependent ApoB‐100 binding to ZnP NCP with and without cholesterol, n = 3. g) Distributions of SN38, Chol‐SN38, and Chol‐SN38 from OxPt/SN38 in different lipoproteins of rat plasmas by ultracentrifugation separation. h) Pharmacokinetic profile of Chol‐SN38 from OxPt/SN38 in rat plasma and its lipoprotein distribution after intravenous injection of OxPt/SN38 at a Chol‐SN38 dose of 14.4 mg kg−1. Data are expressed as means ± SD by Student's two‐tailed t‐test.