Table 2.

Comparable analysis for the association between migraine and the risk of all-cause dementia

Variables	Subjects, No	Dementia cases, No	Person- Years, No	Incidence rate (95% CI) per 10,000 person years	Hazard ratio (95% CI)
Full cohort
Matched Controls	44,195	3,757	348,995	107.7 (104.3–111.1)	1.00
Migraine cohort	44,195	4,800	343,871	139.6 (135.7–143.5)	1.30 (1.25–1.35)
Gender
Men
Matched Controls	14,967	963	110,806	86.9 (81.6–92.5)	1.00
Migraine cohort	14,967	1,274	108,781	117.1 (110.8–123.6)	1.35 (1.25–1.46)
Women
Matched Controls	29,228	2,794	238,190	117.3 (113.0–121.6)	1.00
Migraine cohort	29,228	3,526	235,090	150.0 (145.1–154.9)	1.28 (1.23–1.34)
Age of migraine diagnosis
40–59
Matched Controls	18,948	303	183,685	16.5 (14.7–18.4)	1.00
Migraine cohort	18,948	409	183,332	22.3 (20.3–24.6)	1.35 (1.17–1.57)
60–
Matched Controls	25,247	3,454	165,311	208.9 (202.2–215.7)	1.00
Migraine cohort	25,247	4,391	160,540	273.5 (265.7–281.3)	1.32 (1.26–1.38)
Migraine aura
Matched Controls	44,195	3,757	348,996	107.7 (104.2–111.1)	1.00
Migraine without aura	16,628	1,898	136,279	139.3 (133.1–145.6)	1.29 (1.22–1.36)
Migraine with aura	4,004	456	33,883	134.6 (122.7–147.5)	1.24 (1.12–1.36)
Unspecified	23,563	2,446	173,709	140.8 (135.3–146.4)	1.32 (1.26–1.38)
Time from migraine diagnosis
0–5 years
Matched Controls	44,195	1,577	187,423	84.1 (80.0–88.3)	1.00
Migraine cohort	44,195	2,224	185,691	119.8 (114.8–124.8)	1.42 (1.34–1.51)
6–10 years
Matched Controls	30,552	1,454	116,502	124.8 (118.5–131.3)	1.00
Migraine cohort	30,057	1,754	114,167	153.6 (146.5–160.9)	1.26 (1.14–1.4)
10 years or over
Matched Controls	15,854	726	45,070	161.1 (149.6–173.1)	1.00
Migraine cohort	15,532	822	44,013	186.8 (174.3–199.8)	1.16 (1.05–1.28)