Fig. 4.

Histopathology of the lungs, kidneys, and liver of recipient mice. A Representative micrographs of H&E-stained paraffin-embedded section of the lungs, kidneys, and liver of mice transferred with whole PBMC, T cell-depleted PBMC, or B cell-depleted PBMC from patients with SSc. Bars = 100 μm. B–D Severity of inflammation in the lungs, kidneys, and liver in mice transferred with whole PBMC and mice transferred with T cell-depleted PBMC from SSc patients. E–G Severity of inflammation in the lungs, kidneys, and liver between mice transferred with PBMC and mice transferred with B cell-depleted PBMC from SSc patients. Severity of inflammation was calculated as the percentage of areas affected by the infiltrated inflammation. Statistical significance was determined by Wilcoxon matched pairs test, and p values are indicated