Table 2.

Diagnostic performance of candidate emRNAs for distinguishing localized clear cell renal cell carcinoma (ccRCC) patients from healthy controls in the training and validation sets

mRNA group	Training set				Validation set
	Univariate			Multivariate	Univariate			Multivariate
	p	Youden index	AUC	p	p	Youden index	AUC	p
CUL9	0.0266	0.27	0.611	/	/	/	/	/
KMT2D	0.0002	0.35	0.668	0.0011	< 0.0001	0.29	0.655	0.0013
PBRM1	0.0029	0.30	0.639	/	/	/	/	/
PREX2	< 0.0001	0.62	0.742	< 0.0001	< 0.0001	0.61	0.776	< 0.0001
SETD2	0.0007	0.41	0.680	/	/	/	/	/

Note. AUC of ccRCC diagnostic signature for ccRCC versus healthy = 0.836 (95% CI, 0.765 to 0.893). Logistic regression model (method of stepwise) = 1.21943 × KMT2D + 1.97072 × PREX2 + 1.30485. ccRCC, clear cell renal cell carcinoma; ROC, receiver operator characteristic; AUC, area under the curve