Table 3.

Effect of sustaining local muscle metabolism on glucose concentration at each time point

Time	SPU1 effect at each time point			SPU2 effect at each time point
minutes	N = 15 Control	SPU1	Δ mg/dL	N = 10 Control	SPU2	Δ mg/dL
0	99 ± 2	101 ± 2	NS, p = 0.524	99 ± 3	102 ± 4	NS, p = 0.416
15	132 ± 5	123 ± 4	NS, p = 0.061	132 ± 7	124 ± 5	NS, p = 0.427
30	167 ± 6	157 ± 5	NS, p = 0.092	166 ± 7	147 ± 7	−19 ± 6∗
45	190 ± 7	167 ± 7	−22 ± 5∗∗	193 ± 6	165 ± 7	−28 ± 8∗
60	201 ± 8	169 ± 8	−33 ± 7∗∗∗	206 ± 6	163 ± 7	−43 ± 7∗∗∗
75	198 ± 8	164 ± 8	−34 ± 8∗∗	207 ± 4	159 ± 7	−47 ± 6∗∗∗∗
90	192 ± 9	157 ± 7	−34 ± 7∗∗∗	198 ± 4	151 ± 7	−48 ± 8∗∗∗
105	186 ± 10	155 ± 6	−31 ± 6∗∗∗	191 ± 4	142 ± 6	−49 ± 7∗∗∗∗††
120	175 ± 9	146 ± 6	−29 ± 6∗∗∗	182 ± 5	136 ± 5	−46 ± 7∗∗∗††
135	165 ± 10	134 ± 8	−31 ± 6∗∗∗	176 ± 6	128 ± 5	−48 ± 6∗∗∗∗††
150	146 ± 11	121 ± 8	−25 ± 9∗	154 ± 11	116 ± 7	−38 ± 8∗∗
165	129 ± 11	106 ± 7	−24 ± 10	137 ± 13	103 ± 9	−34 ± 9∗∗
180	117 ± 10	97 ± 7	−20 ± 7∗	121 ± 13	92 ± 9	−29 ± 8∗∗

Mean ± SEM. Effects of SPU contractions were determined by a mixed effects model followed by Tukey’s multiple comparison tests. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 versus sedentary control; †p < 0.05, ††p < 0.01 for SPU2 versus SPU1. N = 15 for SPU1 effects and N = 10 for SPU2. The zero time point was always taken when in the overnight fasted state and sitting inactive before the 3-h 75-g OGTT. See also Figures S10A and S10B for the graphical depiction of the time course for glucose concentrations for these results in Experiment II.