Table 3.

Hazard ratios from Cox Proportional Hazards models comparing the association between presenting with advanced HIV^a and time to and clinical outcomes^a (N = 957)

	Crude analysis			Adjusted analysisb			Maximally adjustedc
	HRf	95% CI	p-value	aHRf	95% CI	p-value	aHRf	95% CI	p-value
First VL test	1.5	1.2, 2.0	0.001	1.2	0.9, 1.6	0.167	1.1	0.8, 1.5	0.442
First viral suppression	1.3	1.0, 1.7	0.040	1.1	0.8, 1.4	0.562	1.0	0.8, 1.4	0.949
Death	5.3	2.5, 11.2	< 0.001	4.4	1.9, 10.2	< 0.001	4.8	2.0, 11.6	0.001
Treatment failured	1.3e	0.8, 1.9	0.247	1.7	1.1, 2.5	0.017	1.9	1.2, 3.0	0.005

^aDefined as presenting to care with CD4 < 200 or WHO Stage 3 and 4

^bAdjusted for district, age, sex, and distance to health facility

^cAdjusted for district, age, sex, distance to health facility, BMI, and method of enrollment

^dTreatment failure was composite outcome that included death, loss to follow-up, or virological failure where virological failure which was defined as having a viral load ≥ 200 copies/ml among those who had previously achieved viral suppression

^eProportional hazards assumption was violated for this model and the hazard ratio should be interpreted as the incidence rate ratio over the 630-day follow-up rather than an instantaneous hazard

^fHR: Hazard ratio, aHR: adjusted Hazard ratio