Figure 5. Tannic acid, gallic acid and salicin each increase KCNQ5 activity at hyperpolarized potentials.
Error bars indicate SEM. n indicates number of oocytes. Statistical comparisons by one-way ANOVA.
A. Mean traces for KCNQ5 expressed in oocytes in the absence (Control) or presence of the compounds indicated (100 μM); n = 4–5 per group.
B. Mean tail current (left) and normalized tail current (G/Gmax) (right) for traces as in A; n = 4–5 per group.
C. Mean current fold increase versus membrane potential for traces as in A; n = 4–5 per group.
D. Mean unclamped oocyte membrane potential for KCNQ5-expressing oocytes as in A; n = 4–5 per group.