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. 2022 Aug 4;55(16):6913–6937. doi: 10.1021/acs.macromol.2c00854

Figure 4.

Figure 4

(A) Dendrimeric histidine- and tryptophan-containing scaffolds with 34 or 62% ethylene glycol (T34 and T62) were synthesized and shown to mediate NLRP3 inflammasome activation via a lysosomal rupture- and cathepsin-dependent mechanism. Reproduced with permission from ref (130). (B) Self-assembling polymer nanoparticles induce ASC speck formation and immunotoxic responses in a composition-dependent fashion, with increasing core octyl methacrylate content mediating maximal immunogenicity. Reproduced with permission from ref (131).