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. 2022 Aug 11;13:927763. doi: 10.3389/fendo.2022.927763

Figure 2.

Figure 2

ANGPTL8 knockout suppresses diet-induced obesity in male mice. (A) Schematic of the experimental design. (B) The overall appearance of WT and ANGPTL8 KO male mice fed an NCD for 20 months. (C) The overall appearance of WT and ANGPTL8 KO male mice fed an HFD for 20 months. (D) Body weight change of WT and ANGPTL8 KO male mice at 10 and 20 months after NCD feeding (n ≥ 6). (E) Body weight change of WT and ANGPTL8 KO male mice at 10 and 20 months after HFD feeding (HFD started at 8 weeks old, n ≥ 4). (F) Macroscopic heart, liver, and kidney appearance of ANGPTL8 KO and WT male mice fed an NCD for 20 months. (G) Macroscopic heart, liver, and kidney appearance of ANGPTL8 KO and WT male mice fed an HFD for 20 months. (H) The weights of the heart, liver, kidney, and white adipose tissue of ANGPTL8 KO male mice and WT male mice fed an NCD for 20 months (n = 4). (I) The weights of the heart, liver, kidney and white adipose tissue of ANGPTL8 KO male mice and WT male mice fed an HFD for 20 months (n = 4).